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Why Glycans

Glycans are complex sugar chains attached to proteins and lipids and are present on the surface of nearly all living cells and many extracellular molecules.

Despite being built from a limited number of monosaccharides, their structural diversity is vast and biologically impactful. Even minor changes in glycosylation can significantly affect the structure and function of biomolecules.

Because of this, glycosylation directly alters efficacy, safety and performance of therapeutic proteins and biologics. Understanding glycosylation in detail is therefore essential in modern life sciences and industrial biotechnology.

Glycans are complex.

Your analysis doesn't have to be.

What We Do

Bringing Glycans into Focus

Complete glycan solutions

Glycan analysis is technically demanding, time-intensive, and often inconsistent across labs.

We change that.

We provide end-to-end expertise in glycan analysis—whether you need high-quality analytical service, or a full analytical platform for your own laboratory.

Our integrated workflows combine optimized chemistry, high-resolution separation, and intelligent data analysis—delivering robust, reproducible, and decision-ready results.

Why Choose Us

Deep Glycomics Specialization

Depth over breadth, exclusively focused on glycans

From Service to Imple­men­tation

Start with outsourced analysis, scale to your own in‑house platform

Any Sample

From purified proteins to complex biological samples

Any Level of Information

From rapid profiling to detailed structural insight

Extensive Experience

Advancing glycan analysis for over 15 years with strong academic and industry impact

Full Support

Training, installation, troubleshooting, application consulting

Any Glycan

From N‑glycans to O‑glycans and glycolipids, any complexity

Any Amount

Only micrograms needed to unlock molecular details

Many Technologies

From xCGE‑LIF to LC‑ and MS‑based workflows

Partnership Approach

Working with you, not just for you

Any Question

Your question not on our list? We design custom solutions

Any Number

From one sample to thousands, we handle it all

Research Highlights

Robert Burock, Léa Chuzel, Thilo Kähne, Udo Reichl, Erdmann Rapp, René Hennig
Frontiers in Molecular Biosciences, 2025
Raider of the lost N-glycans – Localizing rare and frequently overlooked IgG N-glycans with sulfation or bisecting LacNAc
Katharina Böttinger, Christof Regl, Veronika Schäpertöns, Erdmann Rapp, Therese Wohlschlager, Christian G. Huber
Journal of Pharmaceutical Analysis, 2024
“Small is beautiful” – Examining reliable determination of low-abundant therapeutic antibody glycovariants
Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp
Engineering, 2023
Removable Dyes—The Missing Link for In-Depth N-glycan Analysis via Multi-Method Approaches
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Lucrezia Morticelli, Charlotte Rossdam, Samanta Cajic, Dietmar Böthig, Mikhail Magdei, Sugat Ratna Tuladhar, Björn Petersen, Konrad Fischer, Erdmann Rapp, Sotirios Korossis, Axel Haverich, Angelika Schnieke, Heiner Niemann, Falk F. R. Buettner, Andres Hilfiker
Xenotransplantation, 2023
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans
Robert Burock, Samanta Cajic, René Hennig, Falk F. R. Buettner, Udo Reichl, Erdmann Rapp
Molecules, 2023
Reliable N-Glycan Analysis–Removal of Frequently Occurring Oligosaccharide Impurities by Enzymatic Degradation
Arthur Hinterholzer, Jennifer Moises, Christof Regl, Sebastian Schwap, Erdmann Rapp, Christian G. Huber, Mario Schubert
mAbs, 2022
Unambiguous identification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy
Andrew C. Tolonen, Nicholas Beauchemin, Charlie Bayne, Lingyao Li, Jie Tan, Jackson Lee, Brian M. Meehan, Jeffrey Meisner, Yves Millet, Gabrielle LeBlanc, Robert Kottler, Erdmann Rapp, Chris Murphy, Peter J. Turnbaugh, Geoffrey von Maltzahn, Christopher M. Liu, Johan E. T. van Hylckama Vlieg
Nature Communications, 2022
Synthetic glycans control gut microbiome structure and mitigate colitis in mice
Julia Beimdiek, René Hennig, Robert Burock, Oliver Puk, Saskia Biskup, Erdmann Rapp, Anke Lesinski-Schiedat, Falk F R Buettner, Anibh M Das
Glycobiology, 2022
Serum N-glycomics of a novel CDG-IIb patient reveals aberrant IgG glycosylation
Fiammetta Di Marco, Thomas Berger, Wolfgang Esser-Skala, Erdmann Rapp, Christof Regl, Christian G. Huber
International Journal of Molecular Sciences, 2021
Simultaneous Monitoring of Monoclonal Antibody Variants by Strong Cation-Exchange Chromatography Hyphenated to Mass Spectrometry to Assess Quality Attributes of Rituximab-Based Biotherapeutics
Léa Chuzel, Samantha L. Fossa, Madison L. Boisvert, Samanta Cajic, René Hennig, Mehul B. Ganatra, Udo Reichl, Erdmann Rapp, Christopher H. Taron
Microbial Cell Factories, 2021
Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans
Maximilian Lebede, Fiammetta Di Marco, Wolfgang Esser-Skala, René Hennig, Therese Wohlschlager, Christian G. Huber
Analytical Chemistry, 2021
Exploring the Chemical Space of Protein Glycosylation in Noncovalent Protein Complexes: An Expedition along Different Structural Levels of Human Chorionic Gonadotropin by Employing Mass Spectrometry

Frequently Asked Questions

Which sample types can you analyze?

We work with a broad range of sample types, from purified glycoproteins or glycolipids to complex biological materials such as serum, plasma, cell lines, and tissues. Our flexible workflows adapt to different sample complexities, ensuring you receive reliable, high-quality glycan data tailored to your project’s needs.

What is the expected turnaround time?

Turnaround time depends on the sample type, number of samples, analysis depth, and project priority. Most projects are completed within two weeks to six months. We always discuss timelines in advance to ensure the analysis fits your project schedule and deliverables.

Do you offer collaboration opportunities?

Yes. We actively collaborate with partners from both academia and industry. Whether you are exploring new glycan-related research questions, developing advanced analytical workflows, or seeking high-quality glycomics data generation, we are eager to support your goals and move your project forward together.

Can you develop a custom glycan analysis method?

Yes! We develop custom glycan analysis methods tailored to your sample type, research goals, and throughput requirements. Our team supports you from method selection and optimization to implementation, ensuring reliable and high-quality glycan data.

Ready to advance your glycan analysis?

Do you have a pure glycoprotein/glycolipid, a complex biological sample, or a cell line/tissue that needs detailed glycan analysis?

Are you working with large sample cohorts and need fast, reliable, high-quality glycan data?

Unsure which analytical method is the best fit for your project and looking for expert application support?

Planning to bring glycan analysis in-house and need the right products, workflows, and technical guidance?

Whether you need deep structural insights or a complete analytical platform, we are ready to support your next step.

Get in Touch